Yoon-Sik LEE - Seoul National University, Korea

Recently, SERS (surface-enhanced Raman scattering) technology has broadened the applications of Raman spectroscopy in biomedical analysis field. During the last decade, we have developed various multifunctional SERS tagging materials; SERS dots, F-SERS dots, M-SERS dots, and NIR SERS dots, which have many advantages; lack of photo-bleaching, narrow peak band width and single laser excitation is used for detection of multiple targets. They have been successfully utilized in screening and identifying biological molecules in vivo and in vitro system. Through Pioneer Research Center program at SNU, we have developed multiplex SERS analysis system to be used as a diagnostic reagent and for detecting disease such as cancer by combining SERS labeling, nano spectroscopy, bio-MEMS, and biomedical technologies. The multiplex analysis technology requires highly sensitive SERS nanoprobes which can give quantification analysis results. The multiplex analysis system can be applied to develop diagnostic reagents, especially antibodies, and disease diagnosis technology. The current blood tests platforms in hospital can be replaced by the multiplex analysis system using SERS dots, resulting in reducing sample consumption and enhancing the testing efficiency. For this, several platform technologies have been developed, which ultimately can be used for disease monitoring system, such as in vitro cancer diagnosis, in vivo imaging, and point-of-care-testing (POCT), which will become a core technology for ubiquitous health care system in a near future.

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