Assessment of the efficiency of encapsulation of a fluorescent drug using Nanoparticle Tracking Analysis (NTA)

Roberto SANTOLIQUIDO, ALFATEST

The use of nanoparticles in drug delivery is rapidly and continuously growing. Nanoparticles offer excellent pharmacokinetic properties, controlled and sustained release, and targeting of specific cells, tissues or organs. When considering a nanomaterial drug delivery system, size is clearly a key parameter as it directly influences the processes of delivery, uptake, degradation and clearance from the body. However, it is also imperative to have an accurate measurement of the number based concentration of nano-objects and more importantly the concentration of nano-objects loaded with the drug of interest.

This presentation outlines several examples where the methodology of Nanoparticle Tracking Analysis (NTA) is used to characterise nanoparticles for drug delivery purposes, exosomes and others  nano-objects crucial for the Nanomedicine applications.

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